During the first millennium of Christian presence in Ethiopia (from the fourth century), church architecture was first in accordance with, and later partially based on, the basilica plan.Circa the early sixteenth century, a new and unique church plan appeared, circular, concentric, and visceratuant with a square sanctuary, and became the dominant c

Base editors (BEs) are a promising tool for precise base conversion in human cells and animals, while the adeno-associated virus (AAV) is the major vector for human gene therapy.However, the size of the DNA cassette required for BE expression exceeds the 4.7 kb packing capacity of the AAV vector, making dual-AAV approaches based on trans-splicing i

Cardiovascular disease (CVD) complications have contributed significantly toward poor survival of cancer patients worldwide.These complications that result in myocardial and vascular damage lead to long-term multisystemic disorders.In some patient cohorts, the progression from acute to symptomatic CVD state may be accelerated due to exacerbation of

Abstract Hydrogels have shown great potential and value in wound healing.In this study, we construct a mesenchymal stem cell exosomes (MSC-Exos) laden natural biopolymer-based hydrogel with transparent, self-healing, injectable, and tissue adhesive properties to promote corneal regeneration.This hydrogel is synthesized by combining aldehyde-modifie